您当前的位置:主页 > 澳门银河平台 > 正文

澳门银河赌钱网投陈志南、姜学军团队展现癌细胞铁灭亡分子机制

2019-08-17 12:02  作者:澳门银河赌钱网投 点击:次 

(据美国眷念斯隆-凯特林癌症中心) 附:英文原文 Title: Intercellular interaction dictates cancer cell ferroptosis via NF2YAP signalling Author: Jiao Wu,中国工程院院士, a frequent tumorigenic event in mesothelioma。

对肿瘤相关分子CD147在癌希望中的多时相、多阶段和多节点的分子调控机制的原创性研究和转化应用研究处于国际领先职位。

Huijie Bian, can trigger ferroptosis. Ferroptosis contributes to the antitumour function of several tumour suppressors such as p53。

由E-钙粘卵白介导的这种彼此浸染通过激活细胞内NF2(也称为merlin)和Hippo信号传导途径来抑制铁灭亡,直接抑制GPX4,使得恶性间皮瘤的原位小鼠模子中的癌细胞对铁灭亡更敏感,BAP1和延胡索酸酶的抗肿瘤成果。

which are by-products of cellular metabolism. The direct inhibition of GPX4。

这些研究功效证明白细胞间彼此浸染和细胞内NF2-YAP信号在抉择铁卵白灭亡中的浸染,雷同的机制也调理一些非上皮细胞中的铁灭亡,或通过耗尽其底物谷胱甘肽或谷胱甘肽的来历(如半胱氨酸)举办间接抑制。

a similar mechanism also modulates ferroptosis in some non-epithelial cells. Finally,而且凡是对各类治疗具有抗性, genetic inactivation of the tumour suppressor NF2, mesenchymal cancer cellswhich are prone to metastasis,恒久从事炎-癌相关分子CD147系列研究,主要研究偏向:措施性细胞灭亡、分子机制及其在肿瘤产生中的浸染,。

BAP1 and fumarase. Counterintuitively。

创刊于1869年。

细胞生物学与生物药物专家。

最新IF:43.07 官方网址: 投稿链接: 本期文章:《自然》:Volume 572 Issue 7769 ,相关论文于2019年8月15日颁发于国际学术期刊《自然》上, Brent R. Stockwell。

谷胱甘肽过氧化物酶4(GPX4)是一种中枢调理者, Minghui Gao, Xuejun Jiang IssueVolume: Volume 572 Issue 7769 Abstract: Ferroptosis,铁灭亡有助于几种肿瘤抑制因子如p53,空军军医大学(第四军医大学)细胞生物学国度重点学科主任,肿瘤抑制因子NF2的遗传失活(间皮瘤中常见的致瘤事件), and often resistant to various treatmentsare highly susceptible to ferroptosis. Here we show that ferroptosis can be regulated non-cell-autonomously by cadherin-mediated intercellular interactions. In epithelial cells, rendered cancer cells more sensitive to ferroptosis in an orthotopic mouse model of malignant mesothelioma. Our results demonstrate the role of intercellular interactions and intracellular NF2YAP signalling in dictating ferroptotic death, Alexander M. Minikes,拮抗该信号轴使得原癌基因转录共激活因子YAP通过上调几种铁灭亡调理卵白(包罗ACSL4和TFRC)来促进铁灭亡, Zhi-Nan Chen,铁灭亡可以通过钙粘卵白介导的细胞间彼此浸染举办非细胞自主调控,而且还发明NF2-YAP信号通路中的恶性突变可以预测癌细胞对将来铁灭亡诱导疗法的响应性,附属于施普林格自然出书团体,可激发铁灭亡,在上皮细胞中, Yong Li,与缺血性器官损伤和癌症等疾病有关, or indirect inhibition by depletion of its substrate glutathione or the building blocks of glutathione (such as cysteine),与预想相反的是,这一发明为具有间充质或转移性癌细胞对铁灭亡高度敏感的调查功效提供了机制看法,(据中国工程院) 姜学军 姜学军, a cell death process driven by cellular metabolism and iron-dependent lipid peroxidation, and also suggest that malignant mutations in NF2YAP signalling could predict the responsiveness of cancer cells to future ferroptosis-inducing therapies. DOI: 10.1038/s41586-019-1426-6 Source: https://www.nature.com/articles/s41586-019-1426-6 期刊信息